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包衣葡萄糖微珠靶向激活远端肠内分泌信号网络并改善糖耐量的临床 ...
本综述报道了一种创新的口服包衣葡萄糖微珠(APHD-012)通过精准递送葡萄糖至远端小肠,激活内源性肠内分泌信号网络(包括GLP-1、GLP-2、PYY、glicentin等),显著改善糖尿病前期患者葡萄糖耐量(OGTT AUC0–2h及2h血糖值),其疗效媲美GLP-1受体激动剂,且不良反应 ...
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