该研究基于颅咽管瘤的基因突变特征和下丘脑伸展细胞(tanycyte)的致瘤潜能,成功建立了高度模拟人类颅咽管瘤特征的遗传性肿瘤动物模型。 该研究首次证实,小胶质细胞来源的维生素D结合蛋白(VDBP),会在慢性不可预测轻度应激(CUMS)易感小鼠的核心情绪 ...
作者分析了在实验室中进化出的724种恶性疟原虫的基因组,这些恶性疟原虫对118种不同的抗疟疾化合物具有耐药性,其中既包括已有的药物,也包括新的实验药物。 在一项新的研究中,来自剑桥大学的Andrew P. Stewart及其同事们发现,称为中性粒细胞胞外陷阱(NET ...
Top left shows how the in vitro aggregation of the protein TDP-43 (associated with ALS), seen as white blobs, is dependent on the concentration of ATP (measured in millimolar, mM). The same is shown ...
The images display colour-coded signals from the ATP sensor expressed by the mice’s nerve cells. The sequence (from top left to bottom right) shows the drop in ATP levels during a spreading ...