In 2020, news headlines repeated John Moult’s words at the end of a stunning competition: Artificial intelligence had “solved” a long-standing grand challenge in biology, protein structure prediction.

“I’ll be shocked if we don’t see more and more LLM impact on science,” says John Jumper. In 2017, fresh off a PhD on theoretical chemistry, John Jumper heard rumors that Google DeepMind had moved on ...

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...