Balanced synaptic inhibition, controlled by multiple synaptic adhesion proteins, is critical for proper brain function. MDGA1 (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu [MAM] ...

This is a preview. Log in through your library . Abstract Cleavage and release of membrane protein ectodomains, a regulated process that affects many cell surface proteins, remains largely ...

Aη, or A-eta, made an initial splash when scientists reported that these fragments of amyloid precursor protein—products of a heretofore unknown cleavage—dampen neural activity. But how? The story ...

Cerebrospinal fluid (CSF) is a clear and watery liquid that flows in and around the brain and spinal cord. Its functions include protecting parts of the nervous system, delivering nutrients and ...

A research team led by the National Neuroscience Institute (NNI) has uncovered a novel function of the Amyloid Precursor Protein (APP), one of the main pathogenic culprits of Alzheimer's disease. This ...

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors. This amyloid protein, α-S1 casein, ...

In a recent study published in the journal PLOS Biology, researchers used mouse models to demonstrate that neurons were not the only source of abnormal amyloid β proteins contributing to the pathology ...