The downside of prodrugs is potential for drug interactions and differences in metabolism due to genetic polymorphisms. The activity of prodrugs may be diminished or eliminated in the absence of ...

To the Editor: Berde and Sethna (Oct. 3 issue) 1 provide an excellent summary of developmental differences in pharmacology that dictate the appropriate use of analgesics in pediatric patients. However ...

Analgesics are medications that relieve pain. They work either by reducing inflammation or by changing the way the brain processes and perceives pain. Side effects include heartburn, nausea, and ...

Researchers have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys. Researchers at LSU Health New Orleans ...

Sites of action of opioids for pain relief include the brain (cortex, thalamus, hypothalamus, locus coeruleus, amygdala, and periaqueductal gray matter), spinal cord, and peripheral-nerve membrane.

A new study finds that the influence of single analgesic doses of methadone and buprenorphine -- two different opioids -- on driving performance was mild and below the impairment threshold of a blood ...