The surfaces of Gram-negative bacteria are adorned with versatile nanomachines that include Type IV pili and associated secretion systems. These structures are crucial for a range of functions such as ...

Many pathogenic bacteria use special secretion systems to deliver toxic proteins into host cells. Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich have determined the structure of a ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

The beneficial bacterium Pseudomonas protegens protects plants from fungi and bacteria. However, behind this seemingly selfless act lies a complex system by which the bacteria try to occupy a ...

Bacteria have complex molecular machines that help them drive disease. Scientists can now leverage these machines to treat disease instead. It is nice to deliver drugs where you exactly want them, ...

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years. Now Niederweis ...