德琪的这种机制,相当于让T细胞变成了一个高效的“刺客”,双臂高亲和力确保能抓住那些低表达的狡猾靶点,而“快上快下”则让T细胞在完成一次击杀后迅速脱离,重新寻找下一个目标,有效避免了T细胞被过度透支。这种设计最直接的好处是大幅拓宽了药物的安全窗口。
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