Hearing loss is a common and often permanent side effect of cisplatin, a widely used chemotherapy drug for many solid tumors. Cisplatin accumulates in the inner ear, where it damages sensory hair ...

Researchers at Duke University have shown that blocking an enzyme involved in iron regulation not only kills multiple myeloma cancer cells, but also increases the effectiveness of current therapies ...

Two enzymes from the protein disulphide isomerase (PDI) family enable prostate cancer cells to grow, survive, and resist treatment. This discovery, however, could be taken as an advantage to improve ...

The emergence of cancer drug resistance remains one of the most pressing problems in cancer care and there is a critical need to devise approaches to mitigate it. However, the molecular mechanisms ...

Multiple sclerosis (MS) is a chronic, often debilitating autoimmune disease that affects the central nervous system (CNS). This disease causes the immune system to mistakenly attack the protective ...

Enzymes are the molecular machines that power life; they build and break down molecules, copy DNA, digest food, and drive virtually every chemical reaction in our cells. For decades, scientists have ...