CTCF是维持染色质三维基因组结构的关键蛋白，其主要通过与Cohesin复合物互作形成染色质环（CTCF loop），进而调控增强子-启动子互作（EP互作）和基因表达。然而，近年来多项研究发现快速降解CTCF对EP互作和基因表达的影响较弱（Nora et al., 2017; Hsieh et al., 2022 ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

Biology is never as straightforward as we learned in high school. Take sex-linked chromosomes as an example: we’re taught that biological males get XY chromosomes while biological females get two ...