本研究深入探讨白色念珠菌（C. albicans）在口腔癌发生中的作用机制。通过动物模型与临床样本（CHC）结合转录组测序（RNAseq）和全外显子测序（WES），发现C. albicans虽不直接诱发癌变，但可上调增殖相关基因（如Mki67、Ccna2），诱导DNA双链断裂（标记物γH2A.X ...

该研究首次揭示了结直肠癌的重要病因机制——肠道共生真菌白色念珠菌通过其菌丝表面“锚定蛋白”Flo9与具核梭杆菌外膜“对接蛋白”RadD 直接相互作用，促进具核梭杆菌在肠道黏膜的定植，进而加剧其促癌作用 ...

本文系统综述了白色念珠菌（Candida albicans, C. albicans）阴道感染的致病机制、宿主免疫应答及防治策略。文章重点解析了C. albicans的毒力因子（如生物膜形成、表型转换）、风险因素（抗生素滥用、免疫抑制等），并探讨了当前抗真菌疗法的局限性（如耐药性）与 ...

BUFFALO, N.Y. — You might call Candida albicans a shape-shifter: As this fungus grows, it can multiply as single, oval-shaped cells called yeast or propagate in an elongated form called hypha, ...

This educational game simulates breastfeeding complications, equipping nurses with skills to detect and manage fungal infections in the nipple-areola area. Candida species, particularly Candida ...

An estimated 1.5 million deaths worldwide are attributed to invasive fungal diseases annually. 5 Of these, hospital-acquired infections—most frequently caused by species of Candida—account for around ...

BUFFALO, N.Y. -- You might call Candida albicans a shape-shifter: As this fungus grows, it can multiply as single, oval-shaped cells called yeast or propagate in an elongated form called hypha, ...

A protein called Sir2 may facilitate C. albicans' transition from ovoid yeast to thread-like hypha. C. albicans cells that were missing the Sir2 gene were less likely to form true hyphae in lab ...

Zhen C, Wang L, Feng Y, Whiteway M, Hang S, Yu J, Lu H, Jiang Y. (2024) Ontionium bromide exhibits potent antifungal effects by blocking ergosterol plasma membrane localization and triggering ...

Fungi of the genus candida normally live on the skin and inside the body (mouth, throat, gut, and vagina) without causing health problems. Research suggests about 20 percent of women have candida in ...