Cellular injury entails disruptions in a cell's structure or function triggered by factors such as physical trauma, chemical exposure, infectious agents, and oxidative stress. These alterations may ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

After more than a decade of research, scientists have discovered the natural mechanism behind a novel form of cell death ...

A research team has conducted a study exploring the role of the mannose pathway in regulating cell fate decisions in low glucose environments. Their work may hold potential for novel therapeutic ...

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children's Research Hospital published today in ...

Researchers at St. Jude Children's Research Hospital have uncovered a new pathway for mitochondrial cell death that involves the protein BCL-2 ovarian killer, otherwise known as BOK. The discovery, ...

A research team has conducted a study exploring the role of the mannose pathway in regulating cell fate decisions in low glucose environments. Their work may hold potential for novel therapeutic ...

Cancer’s deadliest talent is not rapid growth but the ability to sidestep the internal programs that should make damaged cells self-destruct. Across multiple labs, researchers are now converging on a ...

Here’s what you’ll learn when you read this story: When cells are about to die, they send signals that trigger proteins which are supposed to destroy them, but it doesn’t always happen that way. Some ...

Scientists link TMC protein membrane disruption to hearing loss, showing how mutations, drugs and noise trigger hair cell death and deafness.