本研究针对NAD+ 工业化生产过程中传统提取法效率低、化学合成法条件苛刻等问题,首次解析了嗜热真菌Chaetomium thermophilum来源的烟酰胺单核苷酸腺苷酸转移酶(CtNMNAT)的2.10?晶体结构(PDB:9IW1)。该酶在60°C和pH6.0条件下展现优异的热稳定性(50°C半衰期25.9小时 ...
本研究从海洋来源Chaetomium sp.真菌中分离得到5个结构新颖的chaetoglobosin-麦角固醇杂合二聚体chalasoergodimers A-E(1-5),揭示了包括C-2'取代、NH-1'取代及Diels-Alder环加成等多种二聚化新模式。单体chaetoglobosins(9-12)对非小细胞肺癌细胞(A549)展现出显著细胞毒性 ...
Chaetomugilins G and H were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish, Mugil cephalus, and their absolute stereostructures were elucidated on the ...