本研究揭示了 Cryptococcus neoformans fbp1Δ 疫苗的免疫原性机制，发现胶囊和Cytokine Inducing Glycoprotein 1（Cig1）蛋白共同参与疫苗诱导的Th1免疫应答，Cig1作为Fbp1 E3连接酶的底物，其过表达增强疫苗效果，而Cig1缺失导致保护性免疫减弱，为优化真菌疫苗提供了新靶点。

红ox传感技术用于实时监测隐球菌细胞内氧化状态，研究显示其能有效追踪不同生长阶段及低剂量过氧化氢胁迫下的氧化应激反应，并通过突变体验证特异性。该成果为开发病原真菌合成生物学工具提供新方法。 氧化还原感应与调控对于致病真菌Cryptococcus ...

Fungal infections kill millions of people each year, and modern medicine is struggling to keep up. But researchers at ...

A lab has completed a six-year study to examine the virulence of 38 clinical isolates from various strains of Cryptococcus. Ultimately, the goal is to find ways to stop deadly disease caused by ...

The echinocandin derivative caspofungin (MK-0991, L-743,872) inhibits 1,3-β-D-glucan synthesis and is active against several medically important fungi but is relatively ineffective against ...

What is Cryptococcus, who does it affect and how many people does it kill each year? Cryptococcus is a fungus found in the environment throughout the world that is able to cause disease in humans.

Bacterial and viral are the more prevalent and commonly discussed forms of meningitis, but one infectious disease expert at the University of Alabama at Birmingham says fungal meningitis stemming from ...