强大的线粒体ROS生成诱导效应T细胞端粒DNA中广泛的双链断裂（DSBs），其中DNA修复机制在呼吸爆发期间迅速被超激活以感知和连接DSBs。然而，效应T细胞是否可以利用DNA修复系统同时增强其功能激活在很大程度上仍然未知，特别是在自身免疫的背景下。

Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.

Study establishes for the first time that defective DNA repair may be the major driver of several clinical features associated with a subset of patients with 22q11.2 distal deletion syndrome ...

Most biochemistry labs that study DNA isolate it within a water-based solution that allows scientists to manipulate DNA without interacting with other molecules. They also tend to use heat to separate ...

New study shows that in women with BRCA1 or BRCA2 mutations, their breast cells already carry a clear pattern of DNA “damage ...

BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...

Researchers have unveiled a way to flip genes back on without slicing into the genome, a shift that could make CRISPR far ...