The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Discovery reshapes understanding of how tumor cells repair broken DNA, pointing toward more precise cancer therapies.

Characterization of the tumor immune microenvironment (TIME) and somatic landscape in gastrointestinal (GI) malignancies with MTAP deletions (del). Use of gene expression profiling to examine ...

Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments that can control gene activity in specific cells. These sequences, called ...

Researchers at the University of Bristol have caught DNA-copying enzymes generating long stretches of genetic code without ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...