HDACIs exert a myriad of biological effects in cancer cells, including induction of differentiation/apoptosis, cell-cycle/mitotic arrest and induction of autophagic ...

Histone deacetylase (HDAC) enzymes play a critical role in normal gene-regulation events and the maintenance of homeostasis. However, their dysregulation has been implicated in a variety of disease ...

Protein Expression of a Triad of Frequently Methylated Genes, p73, p57Kip2, and p15, Has Prognostic Value in Adult Acute Lymphocytic Leukemia Independently of Its Methylation Status Patients with ...

Researchers are trying to identify alternative strategies to treat non-small cell lung cancer (NSCLC). They highlight how targeting the histone deacetylase HDAC11 may be a novel therapeutic strategy ...

Histone deacetylase (HDAC) antibodies are used to study the process of histone deacetylation, an essential activity that happens within human cells. Numerous assays currently exist that rely on the ...