HDACIs exert a myriad of biological effects in cancer cells, including induction of differentiation/apoptosis, cell-cycle/mitotic arrest and induction of autophagic ...

This phase I trial evaluated epigenetic modulation of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor by using a histone deacetylase abexinostat in combination with pazopanib to ...

Several new immunotherapeutic antibodies that inhibit checkpoint receptors on T cells to restimulate the immune system to target tumors have been approved to treat advanced stage lung cancer and ...

Histone deacetylase (HDAC) antibodies are used to study the process of histone deacetylation, an essential activity that happens within human cells. Numerous assays currently exist that rely on the ...

Histone deacetylase (HDAC) enzymes play a critical role in normal gene-regulation events and the maintenance of homeostasis. However, their dysregulation has been implicated in a variety of disease ...

Protein Expression of a Triad of Frequently Methylated Genes, p73, p57Kip2, and p15, Has Prognostic Value in Adult Acute Lymphocytic Leukemia Independently of Its Methylation Status Patients with ...

Researchers are trying to identify alternative strategies to treat non-small cell lung cancer (NSCLC). They highlight how targeting the histone deacetylase HDAC11 may be a novel therapeutic strategy ...

Histone deacetylases are enzymes involved in the modification of histones in order to allow DNA to wrap around them tightly. The enzymes achieve this through removal of the acetyl group from the ...