研究人员通过实验证实,当阻断树突状细胞的这条免疫通路后,幼年小鼠不再对过敏原产生皮肤炎症。更重要的是,这种早期干预还影响了远端的器官—那些原本在二次接触过敏原时会爆发剧烈肺部炎症的小鼠,症状明显减轻了。换句话说,皮肤或许是过敏战役的第一战场,但胜负可能在更早的时候就已注定。如果能在皮肤这个源头掐灭过敏的“火种”,或许就能阻止它蔓延到肺部(哮喘)、消化道(食物过敏)等其他器官。
The current research frontier in blastic plasmacytoid dendritic cell neoplasm (BPDCN) is moving toward combination triplet ...
Why do diabetic wounds refuse to heal? A new scientific review highlights how disruptions in the timing and behavior of immune cells may hold the key to understanding this widespread medical challenge ...
Sepsis remains a major challenge in modern medicine, claiming millions of lives each year. For decades, clinical management has largely focused on suppressing excessive inflammation.
免疫细胞的精准迁移是启动有效免疫应答的关键。树突状细胞(DCs)作为专业的抗原呈递细胞,其在内环境中的巡逻及向淋巴结的归巢能力,直接决定了T细胞激活的效率与抗肿瘤免疫的强度。传统观点认为,趋化因子梯度是引导细胞迁移的主导信号。这篇兰州大学口腔医学院2026年2月4日发表于 Science Advances 的研究论文题为 《Nanocollision promotes locomotion of ...
Chronic diabetic ulcers represent one of the most challenging complications in modern healthcare, affecting over 131 million people worldwide and generating approximately $755 billion in annual ...
A new study has revealed that a special group of cells in the intestines tamp down the immune responses caused by exposure to food proteins. Called 'tolerogenic dendritic cells,' these cells enable ...
A new study suggest that using CXCL9 and CXCL10-producing dendritic cells alongside immunotherapy can be a promising strategy to overcome treatment resistance and improve clinical outcomes for ...
Low stress hormones in infancy may drive eczema risk by allowing immune cells to overreact to common allergens.