Multicomponent reactions allow for more bond-forming events per synthetic operation, enabling more step- and time-economical conversion of simple starting materials to complex and thus value-added ...

本研究通过Ugi-Zhu三组分反应合成异噁唑啉酮衍生物，并探究其在逆Diels-Alder反应中的高效合成机制。结果表明溶剂极性显著影响区域选择性，证实了质子化在机制中的关键作用，并利用NMR和计算化学验证了反应路径。 该研究聚焦于逆电子需求Diels-Alder（IEDDA ...

The Diels-Alder reaction is a classic transformation that typically marries a diene (with four π electrons) and an alkene (with two π electrons) to form a six-membered ring—it’s known as a [4+2] ...

Creating rings, or carbocycles, with a six-carbon skeleton is an elementary exercise for synthetic organic chemists. Ask one how it’s done, and the chemist will inevitably point to the stalwart ...

Until recently it was assumed that cycloaddition reactions (also widely known as the Diels-Alder reactions) do not occur in nature, since corresponding enzymes were never discovered. However, it was ...

A computational study focused on the mechanistic pathway of the SpnF-catalyzed cycloaddition reaction leading to Spinosyn A -- tetracyclic natural insecticide produced by the cells of the bacterium ...

In 1928, chemists Otto Diels and Kurt Alder first documented diene synthesis, a chemical reaction important for synthesizing many polymers, alkaloids and steroids. Their work on this mechanism, which ...

Maleic anhydride is perhaps best known as the quintessential dienophile in the Diels–Alder cycloaddition reaction, but it is also used as a ligand in metal complexes and as a feedstock for maleic acid ...