The endoplasmic reticulum (ER) and the secretory pathway are central to the orchestration of intracellular protein trafficking and lipid homeostasis. These dynamic systems comprise a network of ...

AKT, protein kinase B; BAX, B-cell lymphoma-2-related protein X; cGAMP, cyclic-guanosine monophosphate-adenosine monophosphate; cGAS, cGAMP synthase; dsDNA, double ...

PITTSBURGH, Sept. 7, 2022 — Today in Nature, University of Pittsburgh researchers describe for the first time a pathway by which cells repair damaged lysosomes, structures that contribute to longevity ...