The authors describe a method-validation-by-design (MVbD) approach to validate a method over a range of formulations using both design-of-experiment and quality-by-design principles to define a design ...

High level of microorganisms should not be present in non-sterile products for human use as they may cause adverse incidents. As an expert specializing in drug formulation, CD Formulation announces to ...

Lipid nanoparticle formulation has increased over the past two decades. LNPs have proven to be effective nano-based delivery vehicles for cytotoxic chemotherapeutic drugs, nucleic acid therapies and ...

Artificial intelligence and machine learning can help overcome poor solubility and bioavailability. Artificial intelligence (AI) and machine learning (ML) in the biopharmaceutical industry have been ...

Mathematics of Computation, Vol. 79, No. 272 (OCTOBER 2010), pp. 2001-2032 (32 pages) We derive in this paper a unified framework for a priori and a posteriori error ...

Nonclinical dose formulation analysis methods are used to confirm test article concentration and homogeneity in formulations and determine formulation stability in support of regulated nonclinical ...

Spray-dried protein microparticles without MoNi surfactant form paste-like materials (left), whereas those spray dried with MoNi surfactant form injectable suspensions that flow like liquids (right).

Nonclinical dose formulation analysis methods are used to confirm test article concentration and homogeneity in formulations and determine formulation stability in support of regulated nonclinical ...

SIAM Journal on Numerical Analysis, Vol. 35, No. 2 (Apr., 1998), pp. 560-571 (12 pages) A new mixed finite element method is formulated for the Stokes equations, in ...