编者按环状GMP-AMP合成酶（cGAS）和干扰素基因刺激蛋白（STING）的信号通路负责检测细胞内DNA并触发先天免疫反应，近年来已成为肝脏疾病、尤其是其发病机制和特定治疗方面的关键因素。鉴于cGAS-STING通路在肝脏疾病中的广泛参与，已成为探索新型治疗策略的重要靶点。通过靶向抑制STING活性、阻断其下游信号转导或调节通路相 ...

肝细胞癌（HCC）患者cGAS表达水平与术后预后及免疫治疗反应存在双重关联。研究显示cGAS高表达患者术后 DFS（2.37 vs 3.72年，p=0. ...

In all organisms, innate immune pathways sense infection and rapidly activate potent immune responses while avoiding inappropriate activation (autoimmunity). In humans, the innate immune receptor ...

GSK plc has identified cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors and their prodrugs reported to be useful for the treatment of systemic lupus erythematosus or lupus nephritis.

Boehringer Ingelheim Pharma GmbH & Co. KG has described cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors reported to be useful for the treatment of autoinflammatory interferonopathy, idiopathic ...