编者按环状GMP-AMP合成酶（cGAS）和干扰素基因刺激蛋白（STING）的信号通路负责检测细胞内DNA并触发先天免疫反应，近年来已成为肝脏疾病、尤其是其发病机制和特定治疗方面的关键因素。鉴于cGAS-STING通路在肝脏疾病中的广泛参与，已成为探索新型治疗策略的重要靶点。通过靶向抑制STING活性、阻断其下游信号转导或调节通路相 ...

肝细胞癌（HCC）患者cGAS表达水平与术后预后及免疫治疗反应存在双重关联。研究显示cGAS高表达患者术后 DFS（2.37 vs 3.72年，p=0. ...

In all organisms, innate immune pathways sense infection and rapidly activate potent immune responses while avoiding inappropriate activation (autoimmunity). In humans, the innate immune receptor ...

Cyclic GMP-AMP synthase (cGAS) functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING (stimulator of interferon genes) receptor. Shortly after its ...

Boehringer Ingelheim Pharma GmbH & Co. KG has described cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors reported to be useful for the treatment of autoinflammatory interferonopathy, idiopathic ...

GSK plc has identified cyclic GMP-AMP synthase (MB21D1; cGAS) inhibitors and their prodrugs reported to be useful for the treatment of systemic lupus erythematosus or lupus nephritis.