DNA甲基化是真核基因组最经典的表观遗传标记之一。过去几十年里，5-甲基胞嘧啶（5mC）几乎等同于“真核DNA甲基化”；而N 6-甲基腺嘌呤（6mA）则常被认为是原核修饰。随着更灵敏的检测与关键催化酶的发现，尤其在纤毛虫、绿藻、部分真菌等单细胞真核生物中，6mA呈现出稳定分布并与具体的生物功能关联，一个更核心的问题随之浮现：5mC与6mA是两条不同调控通路，还是在不同物种中“用不同化学语言讲同一套 ...

Discover how CRISPR genome editing is revolutionizing medicine. Learn the science of Cas9, current clinical trials, and the future of gene editing.

This is a human-written story voiced by AI. Got feedback? Take our survey. (See our AI policy here.) Artificial intelligence can dash off more than routine emails. It has now written tiny working ...

The William H. Foege Genome Sciences Building at the University of Washington School of Medicine in Seattle contains laboratories, sequencers, computational facilities, and other resources for ...

Genome assemblies from 65 individuals, representing a variety of the world’s populations, are advancing the scientific exploration of complex genetic structural variation. Structural variations are ...

DNA might be too small to see with the unaided eye, but it packs our cells in shocking quantities: More than six and a half feet of DNA lies within every cellular nucleus. It squeezes into such a ...

Most organisms on Earth have the same basic genetic code, but it comes with some flaws. Scientists sought to work out those errors by creating their own artificial genome, which replaced E. coli’s ...

For decades, large portions of the human genome were labeled "junk DNA." New research from Western University and London ...

This activity was supported by Contract No. HHSP233201400020B/HHSP23337045 with the Defense Advanced Research Projects Agency, the Greenwall Foundation, Grant No. 15 ...