The glucose-phosphorylating enzyme glucokinase has a crucial role in glucose homeostasis as 'glucose sensor' of the insulin-producing pancreatic β-cells and as a regulatory step in the conversion of ...
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Diabetes. 2006;55(1):1-12. Glucokinase is required for GSIR in the physiological range of 4-8 mmol/l. Glucokinase is needed for amino acid and fatty acid stimulation of insulin release. Glucokinase ...
A baby girl of Norwegian ancestry was delivered by cesarean section at 36 weeks' gestation (birth weight, 1670 g; length, 42 cm) because of poor fetal growth (Subject III-7 in Family 1 in Figure 1). 6 ...
The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic ...
Rare, naturally occurring gene mutations provide important insights into normal human physiology. We report on a young girl with severe neonatal hypoglycemia due to a novel glucokinase mutation (V91L) ...
Glucokinase activator AZD1656 shows potential benefit for diabetics with moderate to severe COVID-19
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a wide range of clinical features, from completely asymptomatic infections to fatal or life-threatening disease.
Researchers report a new mechanism for regulating glucose uptake by the liver which has implications for type 2 diabetes and its treatment. Abnormalities in glucose uptake by the liver (or hepatic ...
First glucokinase-activator (GKA) approval outside mainland ChinaApproval supports a differentiated approach to Type 2 diabetes (T2D) managementHong Kong will serve as Hua Medicine's launchpad for int ...
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