McArdle disease, also known as glycogen storage disease type V, is an inherited metabolic disorder marked by a deficiency of myophosphorylase, the enzyme essential for the breakdown of glycogen in ...

Glycogen phosphorylase (GP) is a pivotal enzyme responsible for the catabolism of glycogen into glucose, a process intricately linked to blood glucose regulation. In the context of type 2 diabetes, ...

Researchers discover that glycogen and N-linked glycans accumulate in fibrotic regions of the lung and may be important for therapy development. Ramon Sun, a biochemist at the University of Florida ...

In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck ...

“Stored glycogen doesn’t just sit there in the brain; it is involved in pathology,” said Dr. Pankaj Kapahi, the study’s senior author. This buildup causes a dangerous loop—tau blocks sugar breakdown, ...