55例美国H5N1人类病例病毒基因组分析显示，B3.13和D1.1亚型存在M2-S31N和PA-I38M耐药突变，分别导致M2阻断剂交叉耐药和baloxavir敏感性下降17倍，小鼠模型证实后者降低治疗效果。动物源病毒检测到NA-H275Y（3例）及PA-I38T（7例）等耐药突变，提示持续监测抗病毒药物 ...

Oseltamivir-resistant H1N1 influenza viruses carrying the H275Y neuraminidase mutation predominated worldwide during the 2007–2009 seasons. Although several neuraminidase substitutions were found to ...

Since the outbreak of influenza A (H1N1) virus pandemic, almost 300 cases of infection with an oseltamivir-resistant influenza virus have been reported to the World Health Organization as of June 2010 ...

To date, tests of isolates from eight farms in Canada have yielded a rare neuraminidase (NA) protein mutation known as H275Y that has shown resistance to oseltamivir, according to a new research ...

Neuraminidase inhibitors (oseltamivir and zanamivir) are recommended for treatment of severe illness caused by the 2009 pandemic influenza A (H1N1) virus, and their use has also been advocated for ...