为解决药物研发中肝毒性预测难题，如信息分散、缺乏标准、数据异质性等，研究人员开展了 HepatoToxicity Portal（HTP）的研究。他们整合数据构建知识库（HTP-KB）和预测模型（HTP-Pred），模型表现优异，为药物研发提供了有力支持。 在药物研发的漫长征程中，失败 ...

Antirheumatic agents are among commonly used drugs associated with adverse hepatic reactions. Sulfasalazine and azathioprine are among the most important causes of acute hepatotoxicity. Because such a ...

You have full access to this article via your institution. As illustrated in Table 1, none of the routine baseline clinical or laboratory parameters were predictive of the subsequent development of ...

In this review, we define hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent. The distinction between ...

Hepatotoxicity means damage to the liver caused by drugs and other factors resulting in problems in its functioning. Chemicals or drugs that cause hepatotoxicity are called hepatotoxins. In the ...

Up to the 1980s, cell death caused by drugs, chemicals, and other pathophysiologies was primarily considered necrosis. This view radically changed with the discovery of apoptosis and its specific ...

This page lists all known medications that could potentially lead to 'Hepatotoxicity' as a side effect. It's important to note that mild side effects are quite common with medications. The ...

Leading the way: How leading Chinese institutions drive MDT excellence in hepatocellular carcinoma.

NEW YORK, NY, UNITED STATES, January 30, 2026 /EINPresswire.com/ -- Creative Bioarray, one of the leading providers of ...

Given its rarity, drug-related hepatotoxicity may not be seen during the initial clinical trials of a new medication. After approval, when many more patients are exposed, toxic effects that are very ...

Real-world evidence on the efficacy of atezolizumab and bevacizumab in unresectable hepatocellular carcinoma: An institutional experience. This is an ASCO Meeting Abstract from the 2025 ASCO Annual ...