本研究针对Corynebacterium glutamicum（谷氨酸棒杆菌）生产L-高丝氨酸（L-homoserine）效率低下的问题，通过代谢工程策略优化底盘菌株：首先敲除thrB基因获得基础菌株HWZ006（产量20.8 g/L）；随后通过同源建模和分子对接鉴定homoserine kinase（HK）关键位点R240，经饱和突变 ...

Extract: The synthesis in rat and normal human liver homogenates of cystathionine from homoserine+cysteine was studied. When cystathionine was used as substrate, cyst(e)ine was formed and incubation ...