Inositol trisphosphate receptors (IP3Rs) are pivotal Ca²⁺ channels embedded in the membrane of the endoplasmic reticulum. Their activation by inositol 1,4,5-trisphosphate (IP3) and Ca²⁺ gives rise to ...

The field of mathematical modelling of calcium signalling dynamics has evolved into an essential interdisciplinary area that bridges applied mathematics, computational simulation and cell biology.