Experiments reveal that unsaturated lipid membranes promote vesicle fusion and DNA retention during freeze–thaw cycles, highlighting icy environments as potential drivers of protocell evolution. Today ...

In a breakthrough for cardiovascular medicine, researchers have harnessed artificial intelligence to discover unexpected lipid-lowering effects in existing FDA-approved drugs. The study, published in ...

LUMI-lab, an AI-powered robotic platform trained on 28 million molecules, iteratively optimized lipid nanoparticles and identified brominated lipid tails as strong enhancers of mRNA delivery in ...

Integrating AI with advanced robotics to create self-driving labs (SDL) is a promising approach to tackling molecular discovery. A new SDL system, called LUMI-lab, combines large-scale molecular ...

Researchers have identified a lipid-driven biophysical mechanism that allows tuberculosis-causing mycobacteria to survive inside human immune cells, a discovery that could inform novel ...

The procedure of lipid droplet protein co-immunoprecipitation. The experimental process includes ten steps that are indicated in the flowchart. These steps can be summarized into seven key components ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Integrating AI with advanced robotics to create self-driving labs (SDL) is a promising approach to tackling molecular discovery. A new SDL ...

From vaccines to personalized cancer therapies, scientists are studying the use of mRNA across many clinical applications. However, there are several factors that are unique to mRNA drug product ...