Lipid-binding sites and properties were compared in the hetero-oligomeric cytochrome (cyt) b₆f and the yeast bc₁ complexes that function, respectively, in photosynthetic and respiratory electron ...

Lipid kinases are among the promising targets of new classes of drugs, due mainly to class I PI3Kα, which plays a crucial role in carcinogenesis and metastasis. This enzyme is hyperactive in 30-40% of ...

The cytokine-producing signal protein, a target for drug hunters, has additional activators that could be manipulated ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big impact on how well our cells absorb them, paving the way to more efficient ...

Researchers have identified three previously unknown lipid molecules in rice bran, one of which strengthens the skin's barrier and reduces water loss. Named oryzaceramides A–C, these acylated ...

Thyroid hormones are amino acid-based molecules produced by the thyroid gland. Involved in direct or indirect regulation of key metabolic pathways, these molecules play critical roles in the ...