Lymphangiogenesis is an important process that contributes to the spread of cancer. Here we show that insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) induce lymphangiogenesis in vivo. In a mouse ...

Expert Rev Clin Immunol. 2008;4(5):599-613. The immunization of mouse paws with the antigen keyhole limpet hemocyanin emulsified in complete Freund's adjuvant leads to a strong LN response and ...

Phase II Trial of Proteasome Inhibitor Bortezomib in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma Regional lymph node metastasis is a common event in solid tumors and is considered a ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 32 (Aug. 10, 2004), pp. 11658-11663 (6 pages) Spatio-temporal studies on the growth of capillary blood ...

The lymphatic system is essential for the maintenance of tissue fluid balance, immune surveillance and the absorption of fatty acids in the gastrointestinal tract. The lymphatic circulation is also a ...

A new study from Karolinska Institutet, published in Cell Reports, shows that tumor-associated macrophages, which are white blood cells that are found in breast tumors, can both help and hinder the ...

Vascular endothelial growth factors signal the development of tumour-induced lymph vessel growth and enhance lymphatic metastasis in vivo. A poorly understood characteristic of cancerous tissue is its ...

Oncotarget published "Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma" which reported that although tumor-associated lymphangiogenesis correlates ...