In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo. Studies have reported that NK ...
Characterization of an anti-Trop-2-SN-38 antibody-drug conjugate (IMMU-132) with potent activity against solid cancers. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This ...
It describes the cellular and biochemical mechanisms that are responsible for protecting cytotoxic T lymphocytes and natural killer cells from endogenous cytotoxic perforin and granzymes. Structural ...
Good news for the human immune system: researchers from MedUni Vienna's Departments of Dermatology and Surgery have managed to ascribe an immunological memory function to a subset of cytotoxic NK ...
Lymphocytes mediate cytotoxicity by polarized release of the contents of cytotoxic granules toward their target cells. Here, we have studied the role of the calcium release-activated calcium channel ...
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers have created natural killer cells -- a type of immune cell -- with measurably stronger activity against a form of ...
LGL leukemia represents 2% to 5% of chronic lymphoproliferative disorders in North America and Europe and 5% to 6% in Asia. Recently, the incidence of LGL leukemia has been published from two ...
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