本综述系统探讨了吩噻嗪结构类似物（BM1、BM2、MJ1、MJ2）通过调控p53依赖性信号通路（包括MDM2-p53相互作用、BCL2介导的线粒体凋亡及AIFM2相关铁死亡）在结肠癌HCT116细胞模型中的抗癌机制。研究通过MTT法测定IC50、显微观察细胞形态及RT-qPCR分析关键基因表达，证实 ...

本研究针对抗生素耐药性胞内菌感染临床治疗难题，发现天然产物去氢吴茱萸碱(DEHD)可通过靶向宿主MDM2蛋白(KD=68.34μM)激活P53-AMPK-mTOR信号通路，诱导V-ATPase介导的溶酶体酸化和自噬发生，显著增强头孢克肟等抗生素对沙门氏菌、李斯特菌等胞内病原体的清除效果 ...

Our data suggest that immunopositivity of p14ARF together with a low expression of MDM2 contributes to accumulation of the wild-type p53, and that deregulation of the p53-MDM2-p14ARF pathway is ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality. Targeting oncogenes and their interactive partners is an effective ...

Researchers from the Chinese Academy of Sciences and collaborators reported on the discovery and preclinical characterization of JN-122, a potent spiroindoline derivative that showed a Ki value of 0.7 ...

Myelofibrosis causes anemia, splenomegaly, and other symptoms, creating unmet treatment needs. The POIESIS trial explores navtemadlin as an add-on to Jakafi for suboptimal responders. Navtemadlin ...