C1q is the initiating component of the classical complement pathway and plays a critical role in activating macrophages and microglia through receptor-mediated signaling. Dysregulated C1q activity ...

Central to this evolution is RB-1355, a novel therapeutic comprised of autologous macrophages. Derived from a patient’s own circulating monocytes, these cells undergo a sophisticated transformation ...

An innovative combination of methods to identify and study how macrophages function could potentially revolutionize the diagnosis and treatment of various diseases. Macrophages play a critical role in ...

Melanin can either protect or worsen hereditary hearing loss depending on genetic context, as reported by researchers from Japan. Using genetically engineered mice lacking the SLC26A4 gene, the ...

Atherosclerosis represents a chronic inflammatory disease characterized by the accumulation of lipid-laden macrophage foam cells within arterial ...

More than 300,000 people suffer a heart attack in Germany every year. The heart muscle is then no longer supplied with sufficient blood and oxygen, and part of the tissue dies and scars. Unlike the ...

Researchers in Japan have identified a striking new way immune cells strip DNA out of dying neighbors, a process they call ...

Non-steroidal anti-inflammatory drugs (NSAIDs) are classically defined by cyclooxygenase (COX) inhibition, yet increasing evidence shows that many NSAIDs ...