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生物通
2 个月
MCJ通过调控线粒体电子传递链流量促进脂代谢驱动的肿瘤细胞增殖与 ...
本研究揭示了线粒体蛋白MCJ通过调控电子传递链(ETC)电子流向,将代谢模式从复合物I(CI)依赖转向复合物II(CII)依赖,从而促进脂肪酸氧化(FAO)和脂质合成,增强肿瘤细胞增殖迁移能力。该发现为靶向CII呼吸的肿瘤治疗策略提供了新思路。 在肿瘤生物学 ...
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