Loss and dysfunction of synapses have been linked to age-related cognitive decline and observed in Alzheimer's and other ...

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

Announcing a new article publication for BIO Integration journal. Alzheimer's disease (AD) is a neurodegenerative disorder ...

Researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer's disease. The study also integrates drug databases with real ...

Until now, conventional 3D cell cultures have often been either too rigid or too unstable to realistically reproduce the ...

Scientists broadly agree that both apolipoprotein E and microglia are necessary ingredients for amyloidosis. In mice devoid of ApoE, or of their microglia, scant plaques form. Now, a sweeping study ...

When young donor myeloid cells are transplanted into aging mouse brains, they quickly adopt aging phenotypes. In contrast, old myeloid cells transplanted in young brains take on a more youthful aspect ...

A growing body of research points to chronic, low-grade inflammation inside the brain as a possible accelerant of Alzheimer’s disease, not just a bystander response to damage already done. The 2024 ...

A Dartmouth study published in Nature Communications reveals that immune cells in the brain use a surprising two-step process to power their search-and-destroy missions. When immune cells rush to ...