Cell-based immunotherapies have transformed cancer treatment, yet their widespread use remains constrained by safety risks, ...

Chimeric antigen receptor natural killer (CAR-NK) cell therapy is emerging as a promising next-generation immunotherapy with ...

They are called “Natural Killer” (NK) cells for a reason. These cytotoxic lymphocytes, a part of innate immunity, are the body’s cellular “boots on the ground,” capable of swiftly and ferociously ...

A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates ...

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, ...

MIT and Harvard scientists have designed an advanced type of immune cell called a CAR-NK cell that can destroy cancer while avoiding attack from the body’s own immune defenses. This innovation could ...

Interleukin-2 (IL-2) is a potent immune stimulator able to elicit strong antitumor T-cell responses. However, high-dose IL-2 therapy is limited by severe vascular toxicities resulting from widespread ...