研究发现剪接因子SRSF1不仅对于骨骼肌卫星细胞的增殖至关重要，而且调控着神经肌肉接头在小鼠出生后进一步的成熟过程 骨骼肌卫星细胞是小鼠骨骼肌组织出生后发育阶段发挥主要作用的干细胞群体，其在围产期阶段的增殖是小鼠出生后骨骼肌组织快速生长的 ...

神经肌肉接头（NMJ）功能障碍会引发严重运动疾病，现有研究受限于缺乏精准人类模型。研究人员开发快速 iPSC 衍生 NMJ 模型研究肌萎缩侧索硬化（ALS），发现 SOD1G85R突变运动神经元（MNs）主导 NMJ 细胞病变，该模型为相关研究及治疗提供助力。 在人体中，神经 ...

The neuromuscular junction (NMJ) is a specialised synapse responsible for translating neuronal signals into muscle contractions, forming the basis of voluntary movement and postural control. Integral ...

A key regulator of the neuromuscular junction, the transcriptional co-activator PGC-1α, is a potential target for Duchenne muscular dystrophy therapy. You have full access to this article via your ...

New research shows how repetitive nerve stimulation and single fiber electromyography can help diagnose disorders such as myasthenia gravis. A new report highlights the strengths and shortcomings of ...