在真核生物中，由小RNA介导的基因沉默机制是保护基因组完整性、抵御转座子入侵的重要手段。然而，出现了一个逻辑上似乎自相矛盾的环节：为了沉默转座子，细胞必须先以转座子为模板，转录产生后续用于靶标转座子的RNA。如何精准识别并转录那些本应处于抑制状态的转座子序列，是该领域长期以来未解的关键问题之一。近日，SCI ...

To understand the human genome, scientists focused on protein-coding genes and their functions for decades. This has given us ...

Long non-coding RNAs exist in the so-called "Wild West" (99%) of the human genome that is currently understudied. Not only does this finding have treatment implications for patients with ...

A team from University of Toronto Engineering is the first to synthesize long noncoding RNA (lncRNA) outside the cell—a new approach to drug discovery that has already yielded some promising ...

Impact of variant allele frequency (VAF) of TP53 alterations and Signatera circulating tumor DNA (ctDNA) monitoring for patients (pts) with advanced urothelial carcinoma (aUC) treated with enfortumab ...

Retinitis pigmentosa (RP) is a genetic eye disorder affecting around one in 5,000 people worldwide. It typically begins with night blindness in youth and progresses to tunnel vision as ...

In RNA molecules, the 5′ untranslated region (UTR) is located directly upstream of the start codon and plays a crucial role in post-transcriptional regulation by controlling RNA stability, cellular ...

Explore the breakthrough of lab-made lncRNA by University of Toronto Engineering for new drug discovery potential.

The expression of genes has to be very carefully controlled by cells; serious problems can arise when genes are expressed in the wrong places, at the wrong times, or at the wrong levels, for some ...