Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

Fighting chemotherapy-resistant cancers remains one of the most challenging tasks in the clinic, and the battle is often lost. Artificial nucleoside or nucleobase analogues (antimetabolites) ...

Fluorescent nucleosides, in which a natural nucleobase is replaced by a luminescent analogue, have emerged as indispensable tools for elucidating the structure, dynamics and interactions of nucleic ...

Dr. Logue's research interests are in the application of organic synthesis to carbohydrates, C-nucleosides, and nucleotide analogues. C-nucleosides are nucleosides that contain a carbon - carbon ...

Due to the COVID 19 pandemic and the associated intensive search for therapeutics and vaccines, the chemical substance class of nucleosides is experiencing an enormous increase in interest. Natural ...

Nucleotides are the phosphate esters of nucleoside and are the building blocks of DNA and RNA. All nucleotides have three components: a nitrogen-containing heterocyclic base, a pentose sugar, and a ...

Pathogen recognition is based on the presence of Toll-like receptors (TLRs), which detect pathogen-associated molecular patterns (PAMPs) to coordinate the immune cascade. These receptors are encoded ...

Nucleosides and nucleotides remain one of the most fruitful drug classes, providing about 50% of antiviral drugs and 20% of cancer drugs used in the UK. Nucleoside and nucleotide chemistry constitute ...