孕烷X受体（PXR）是一种核受体，可被多种化合物激活，对药物有效性和安全性产生影响。这给药物开发带来了挑战，因为针对其他蛋白质设计的化合物必须避免PXR激活，同时保留对目标靶点的效力。 孕烷X受体（PXR）是一种核受体，可被多种化合物激活，对药物 ...

本研究发现PXR激活通过双重机制维持尿酸稳态，抑制XOD活性并增强ABCG2表达，从而减少尿酸积累并改善高尿酸血症肾病（HN）的肾损伤。机制研究表明PXR通过抑制NRF2泛素化并促进其磷酸化（S40位点），激活NRF2信号通路，从而调节抗氧化和抗纤维化基因表达。

【导读】据报道，孕烷X受体（PXR）可调节糖脂代谢。肠道屏障功能障碍，导致代谢紊乱。然而，肠道PXR在代谢疾病中的作用，在很大程度上仍然未知。团队的研究结果表明，肠道选择性PXR激活，调节B3galt5表达并维持代谢稳态，使其成为肥胖症的潜在治疗策略。

The inhibitory effect of PXR on p53 may have broad implications for our understanding of PXR-regulated responses and the role of PXR-mediated protein–protein ...

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize ...

Researchers at the University of Oulu have identified a previously unknown mechanism in humans that may explain why certain medicines and environmental chemicals disrupt the balance of sex hormones.

Researchers at the University of Oulu have identified a previously unknown mechanism in humans that may explain why certain medicines and environmental chemicals disrupt the balance of sex hormones.