因此，非氧化性PPP被敲低的T细胞表现出持久性降低和抗肿瘤功效受损。总之，该研究确立了非氧化性PPP是CD8⁺T细胞中一个关键的代谢调节器，对于增强免疫治疗和疫苗策略具有重要潜力。

Isoprenoid biosynthesis is a fundamental metabolic process that produces a vast array of naturally occurring compounds essential for cellular structure and function. In most eukaryotes, the mevalonate ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...

A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST) has revealed metabolic frailties in the cancer cells that ...

Scientists have uncovered a hidden weakness in one of the deadliest childhood cancers. The tumors, which spread quickly and are notoriously hard to treat, rely on a sugar-processing pathway to survive ...

Researchers have discovered that activating the pentose phosphate pathway makes antitumor CD8+ T cells more likely to stay in an immature, stem-like, “precursor” state. Combining this metabolic ...

Parkinson’s disease may begin reshaping the body’s chemistry years before the first tremor or stiffness appears. A growing body of peer-reviewed research now ties specific metabolic disturbances, from ...

Role of ATP homeostasis in mitigating chilling injury of postharvest commodities. A right balance between eATP generation and sufficient eATP scavenging is essential for generating sufficient iATP ...

Image of soil with a close-up of a bacterium and the cellular pathways involved in carbon dioxide productions. Available substrates from soil organic matter are processed through specific pathways ...

Phosphate is mainly used in the form of fertilizer for crops and animal feed supplements. Only 5 percent of world phosphate production is used for other applications, such as corrosion prevention and ...

For a carbon-neutral bioeconomy, processes are needed that can efficiently capture CO 2 and convert it into valuable products. Formic acid, or more specifically its salt, formate, is considered a ...