因此，非氧化性PPP被敲低的T细胞表现出持久性降低和抗肿瘤功效受损。总之，该研究确立了非氧化性PPP是CD8⁺T细胞中一个关键的代谢调节器，对于增强免疫治疗和疫苗策略具有重要潜力。

Isoprenoid biosynthesis is a fundamental metabolic process that produces a vast array of naturally occurring compounds essential for cellular structure and function. In most eukaryotes, the mevalonate ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...

Researchers have discovered that activating the pentose phosphate pathway makes antitumor CD8+ T cells more likely to stay in an immature, stem-like, “precursor” state. Combining this metabolic ...

A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST) has revealed metabolic frailties in the cancer cells that ...

In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck ...