Confocal microscopy is performed with nuclear reporters and stains, nuclear segmentation with ilastik is conducted, and a machine learning method is used to classify the ploidy of each nucleus. Colors ...

UConn Center on Aging researchers have published a new editorial in the journal Aging titled "Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?" In ...

“Our work highlights the need to study polyploidy and senescence in concert to understand their roles in aging, cancer, and therapeutic resistance.” “Our work highlights the need to study polyploidy ...

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies. Polyploidy often occurs in human diseases and cancers, and its ...