The proteasome is a fundamental component of eukaryotic cellular machinery, responsible for the precise degradation of intracellular proteins. By orchestrating the breakdown of both misfolded and ...

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...

Neuronal membrane proteasomes are labeled with a red compound and appear in a subset of sensory neurons that are labeled with green compound. Note, not all green labeled neurons have the red label, ...

This breakdown of proteasome function is involved in many complex diseases and aging. Booster’s approach is a departure from current targeted protein degradation methods, which tag single disease ...

Booster Therapeutics has launched with $15 million in seed financing and a mission to take on the current crop of targeted protein degraders. The Berlin-based biotech is working on a new class of ...