Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

Proteins are made of chains of amino acids, and a basic tenet of biology is that the sequence of amino acids determines how a protein folds into a 3D shape which, in turn, dictates the protein’s ...

Enzymes with specific functions are becoming increasingly important in industry, medicine and environmental protection. For ...

A multicolored 3D model of an enzyme binding double-stranded DNA against a light purple background Computational enzyme design could allow for reactions not seen in nature. Credit: Ian Haydon ...

Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to control these interactions is of great interest to biologists.

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

Drug developers have historically glued their attention to targeting the precise and fine-tuned protein structures underlying biological function. Yet this approach misses over 50% of the human ...

The “ChatGPT moment” for biology proceeds to unfold as protein language models, or machine learning tools trained on large databases of protein sequences, work to decode the language of life with the ...

Proteins play a key role in the life sciences - from basic research and biotechnological applications to the development and manufacturing of pharmaceuticals. Scientists at the Technical University of ...