Scientists at the Agency for Science, Technology and Research (A*STAR) and the Shanghai Institute of Immunology (SII), along with their international collaborators, have dissected the key signaling ...

In the world of protein degradation, sometimes a spanner in the works isn’t an inconvenience but the desired result. Paris-based Enodia Therapeutics has launched out of France’s Pasteur Institute and ...

CHAPEL HILL, N.C. – Researchers at the UNC School of Medicine, UNC McAllister Heart Institute, and the UNC Lineberger Comprehensive Cancer Center characterized the expression of thousands of cardiac ...

One of the most important classes of human enzymes are protein kinases - signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism. Dysfunction ...

When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein's active site so it can't function and wreak havoc. New strategies for dealing with these ...

Researchers have mapped out the proteins implicated in the early stages of motor neurone disease (MND). They have developed a longitudinal map of the proteins involved in MND across the trajectory of ...

Researchers have found that proteins and pathways involved in inflammation are associated with changes in bone mineral density (BMD) over time. The research, could potentially lead to the ...

Drugs that interrupt the death of healthy bone cells and induce the death of cancerous cells located in bones can prevent or reduced cancer associated bone weakness and improve treatment outcomes for ...

The pathway leading to the telltale sign of ALS, protein aggregation in the cytoplasm of motor neurons, has been revealed. Researchers from the University of California – San Diego (CA, USA) have ...

A new study discovers how nitric oxide triggers a biochemical domino effect in the brain, leading to mTOR overactivation in ...