While the Phase 3 trial of vilobelimab in ulcerative pyoderma gangrenosum (PG) was terminated earlier this year due to ...

On December 30, 2025, InflaRx reported detailed Phase 3 data analyses for vilobelimab in pyoderma gangrenosum (PG), a rare, difficult-to-treat ulcerative skin disease, following the trial’s early ...

Pyoderma gangrenosum was first described as an extraintestinal manifestation of inflammatory bowel disease (IBD) by Brunsting and colleagues in 1930. 1 They described painful enlarging necrotic ulcers ...

People who have an inflammatory bowel disease like ulcerative colitis often have problems caused by inflammation in other parts of their bodies. One of these is a skin condition called pyoderma ...

Leg ulcers form when skin on your leg breaks open. These breaks or sores let air and bacteria travel into your skin’s tissue. For most people, leg ulcers will heal on their own and won’t need medical ...

A 59-year-old woman with systemic lupus erythematosus presented with a 1-month history of an enlarging, exquisitely painful ulcer on her left calf (Figure 1). She reported that it had occurred ...

A 58-year-old woman presented to our emergency department with painful ulcers on the right side of her neck and on her left elbow. The ulcers, which had begun after minimal trauma, had increased in ...

A young father-of-six has contracted an ultra-rare skin disease, with doctors from one of the most respected medical institutions in the world giving him just six months to live. Ryan Becker of ...

It is thought to affect around one in 100,000 people in the UK and US. Pyoderma gangrenosum is believed to occur as a result of a pre-existing condition such as ulcerative colitis, Crohn's disease or ...